"I am overjoyed to be co-hosting the third "Undoing Aging" conference together with Michael Greve, thanks to the generosity and hard work of Michael’s Forever Healthy Foundation and their team. 

For a first time, we have company pitches from the rejuvenation startup forum and a special "Rejuvenation Now" session highlighting the first generation of human rejuvenation therapies that are either currently in clinical trials or are available today. And again, we are assembling a huge variety of world-leading speakers whose research spans all aspects of rejuvenation biotechnology."

Aubrey de Grey

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Program and schedule are provisional and might change due to the recent rescheduling of the conference:

Wednesday, October 21st

12:00   Registration

1:00   Snacks

1:20   Welcome: Aubrey de Grey & Michael Greve

​Opening Keynote

​1:30 - 2:30 Ned David, Co-founder and President of UNITY Biotechnology ​

​3:00 - 5:00 ​Session 1: Rejuvenation Now

​The main focus of Undoing Aging is relatively early-stage research that seems likely to contribute to health-extending therapies in years to come. But what can be done today? While there is justifiable skepticism regarding the value of most nutritional supplements in slowing aging, a variety of recent work has revealed that some already-available interventions (some of them being nutraceuticals, others being approved drugs) stimulate bona fide damage repair, i.e. rejuvenation.​ ​

Michael Greve, Forever Healthy Foundation Isabelle Schiffer, Forever Healthy Foundation Paul Robbins, University of Minnesota Medical School​ Richard Siow, King's College London ​Jamie Justice, Wake Forest School of Medicine ​

5:30 - 8:00 Session 2: Novel approaches to defeating cancer

The cancer therapy world has been transformed by the past decade's discoveries of new ways to energise the immune system against tumours, but it is too early to declare that cancer immunotherapy will obviate all other approaches. In this session we will hear about radically novel strategies that may be effective against an exceptionally wide variety of cancer types.

Short talk from submitted abstracts Short talk from submitted abstracts Jerry Shay, University of Texas Southwestern Medical Center ​Vera Gorbunova, University of Rochester Henri Jasper, Buck Institute for Research on Aging “Are short-lived invertebrates still valuable for biomedical gerontology?” - A debate between Aubrey de Grey and Gordon Lithgow, Buck Institute for Research on Aging ​

8:00 ​Welcome Reception & Networking

​
Thursday, October 22nd

8:30 ​Coffee & Bites

9:00 - 10:45 Session 3: Rejuvenating and enhancing the immune system​Regenerative medicine

The immune system declines in function with age, and comprehensive rejuvenation must reverse this. But also, as we understand immune responses better, ways are emerging to supercharge them to work more powerfully and more robustly, not only against infections but also in eliminating harmful cells and substances. ​

Short talk from submitted abstract Atsushi Okuma, Hitachi, Ltd. · Center of Exploratory Research ​Amit Sharma, SENS Research Foundation ​Matthew O'Connor, Underdog Pharmaceuticals ​

​11:15 - 1:00 ​Session 4: Organellar and cytosolic damage repair​

​​The molecules that populate our cells are in a constant state of activity, and inevitably accumulate damage over time in spite of the plethora of automatic repair systems that the cell contains. Enhancing those systems is central to the rejuvenation paradigm, and in this session we will discover some of the most exciting recent advances to that end. ​

Short talk from submitted abstracts Caitlin Lewis, SENS Research Foundation Tilman Grune, German Institute of Human Nutrition and University of Potsdam Dieter Willbold, University of Düsseldorf and Forschungszentrum Jülich

1:00 ​Lunch

​2:00 - 3:30 ​Session 5: Startup ForumAbstracts

6 Company pitches from Rejuvenation Startup Forum companies

4:00 - 5:45 ​Session 6: The Genome

Our genome, as the repository of almost all the information underpinning the way the body works (including how the body maintains and repairs itself as well as it does), is of intense interest to gerontologists. How is the genome itself maintained throughout life? How can we make it be better maintained? How does it determine species differences in rates of aging? All these questions will be addressed in this session.​ ​

Short talk from submitted abstracts Laura Niedernhofer, University of Minnesota Jessica Tyler, Weill Cornell Medical College, New York João Pedro de Magalhães, University of Liverpool

​6:15 - 8:00 Session 7: Eliminating Senescent Cells

The work that will be described in our opening keynote is one of a range of approaches being taken to the removal of the dysfunctional cells that, though not dividing uncontrollably like cancer, accumulate during life to the detriment of physiological function. In this session we will learn about some of the less well-known alternatives to Unity's drugs.

Short talk from submitted abstracts Tamir Chandra, University of Edinburgh Lynne Cox, University of Oxford ​"Is abrogation of hyperfunction a viable anti-aging strategy?" - A debate between Aubrey de Grey and ​Mikhail Blagosklonny, Roswell Park Comprehensive Cancer Center ​

8:00 ​Networking

  
​Friday, October 23rd

8:30 Coffee & Bites

9:00 - 10:45 ​Session 8:  Restoring and rejuvenating lost cells

In most tissues, when cells die they are replaced by the division and differentiation of other cells - but sometimes this does not occur, with the result that cellularity progressively declines, eventually to pathogenic levels. That damage can be repaired with stem cells, tissue engineering or stimulatory factors, and in this session we will hear about a variety of latest advances in those areas. ​

Short talk from submitted abstract Jordan Miller, Mayo Clinic, Rochester, Minnesota Jeanne Loring, Scripps Research Institute, La Jolla, California Georgina Ellison, King's College, London

11:15 - 13:00 ​Session 9:  Extracellular Damage Repair

​The proteinaceous lattice that holds our tissues and organs together is subject to only very slow (if any) natural turnover, and accumulates a variety of deleteious structural changes over time. These include both excess and depletion of matrix material such as collagen, as well as molecular changes to it. We will hear in this session about techniques for repairing such damage.

Short talk from submitted abstracts Christian Schafmeister, Temple University, Philadelphia Gary Fisher, University of Michigan Chen-Ming Fan, Carnegie Institution for Science, Washington, DC ​

1:00 ​Lunch

2:00 - 3:30 ​Session 10: Startup Forum

6 Company pitches from Rejuvenation Startup Forum companies

4:00 - 5:45 ​Session 11: Intercellular Communication

No cell is an island. The circulation is teeming with molecules, vesicles and whole cells that are in a process of regulated transit from one cell type to another. As we learn more about the nature of such communication, we are becoming more and more able to manipulate it for damage repair, as we will learn from these speakers.

Short talk from submitted abstracts Duncan Ross, Kimera Labs, Inc Ke Cheng, University of North Carolina tba

6:15 - 8:00 ​Session 12: Epigenetic Age

Humans age really slowly compared to most other species, albeit not slowly enough for the participants in this conference. This poses the problem of determining whether an intervention - even a damage-repair intervention - is actually working to restore our physiology. There is, therefore, a huge need for surrogate measures of how much damage the body carries - in other words, how close it is to exhibiting physiological decline. Epigenetic clocks have huge potential in this regard.

Short talk form submitted abstract Wenyu Zhou, Stanford University Adiv Johnson, Nikon Instruments Steve Horvath, University of California ​

8:00 Party